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Azido impurities in drug substances and drug products

Azido impuriteis compounds have an azide functional group, which is linear, polyatomic anion consisting of three nitrogen atoms with the formula N3. Its structure can be represented as −N=N+=N−. Organic azides are organic compounds having the azido functional group attached to the organic compound (R) which is represented as RN3. This R may be alky,

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Nitrosamines in drug substances and drug products

N-nitroso compounds, also called Nitrosamines, are a class of indirect-acting mutagens, as their metabolic degradation leads to the formation of the DNA-alkylating diazonium ion.

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