Partition Coefficient and Dissociation Constant

A) Partition Coefficient

1. Determination of Partition Coefficient as per OED guidelines
2. Determination of Dissociation Constant as per OECD guidelines
3. Determination of pKa

B) Determination of pKa by Technique

1. Potentiometric method
2. Spectrophotometric method
3. Liqid-liquid partition method